The emergence of user-generated content, and the rise of patient involvement in Health 2.0 is radically changing research in both discovery and clinical practice. It’s raising important questions. What is peer review? What is evidence? And what’s appropriate methodology in a world in which data are being generated and released from so many diverse sources so quickly? We’ll be looking across the spectrum from genomics to clinical trial recruiting all the way to clinical research and decisions made by providers and consumers in everyday practice.