Online social networks in health are changing rapidly. Less than five years ago the transformation from simple bulletin boards and listservs was just underway. Now online communities are becoming robust tracking tools for longitudinal data that can be mined for clinical insights and therapeutic activity. The traditional health care system is beginning to take notice and test the integration of online communities in their programs. How will this evolve in the next few years? Benjamin Heywood (President and Co-Founder, PatientsLikeMe), Gideon Mantel (Co-Founder and Chairman of the Board, First Life Research), and Gilles Frydman (Founder, ACOR) come together in this panel to discuss their predictions.